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Related Experiment Videos

Premedication for fibreoptic bronchoscopy.

P J Rees, J G Hay, J R Webb

    Thorax
    |August 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Premedication with atropine, papaveretum, or diazepam showed no significant differences for fiberoptic bronchoscopy. However, diazepam provided notable sedation and reduced coughing, according to both patients and bronchoscopists.

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    Area of Science:

    • Pulmonology
    • Anesthesiology
    • Clinical Pharmacology

    Background:

    • Fiberoptic bronchoscopy requires effective premedication for patient comfort and procedural success.
    • Commonly used agents include anticholinergics like atropine and sedatives such as diazepam.
    • Optimizing premedication regimens is crucial for improving patient tolerance and reducing procedural complications.

    Purpose of the Study:

    • To compare the efficacy of different intramuscular premedication regimens for fiberoptic bronchoscopy.
    • To evaluate patient and bronchoscopist assessments of sedation, tolerance, and adverse effects.
    • To investigate the additional sedative and antitussive effects of intravenous diazepam when combined with intramuscular atropine.

    Main Methods:

    • A randomized, double-blind trial involving 60 patients undergoing fiberoptic bronchoscopy.

    Related Experiment Videos

  • Comparison of three intramuscular premedication groups: atropine alone, atropine plus papaveretum, and atropine plus diazepam.
  • A second study compared intravenous diazepam (10 mg) with saline after intramuscular atropine (0.6 mg).
  • Patient-reported outcomes and bronchoscopist assessments were collected.

    • Main Results:

    • No significant differences in efficacy were observed between the three intramuscular premedication regimens based on patient or bronchoscopist evaluations.
    • Bronchoscopists often perceived atropine alone as having a sedative effect, with more optimistic assessments of tolerance and sedation than patients reported.
    • Intravenous diazepam, when added to intramuscular atropine, resulted in significant sedation and reduced coughing, as noted by both patients and bronchoscopists.

    Conclusions:

    • Standard intramuscular premedication regimens (atropine, atropine plus papaveretum, atropine plus diazepam) offer comparable outcomes for fiberoptic bronchoscopy.
    • Patient and endoscopist perceptions of sedation and tolerance may differ.
    • Intravenous diazepam provides significant benefits in terms of sedation and cough suppression during fiberoptic bronchoscopy.