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Structural and functional development of the nephron.

L Larsson, A Aperia, G Elinder

    Acta Paediatrica Scandinavica. Supplement
    |January 1, 1983
    PubMed
    Summary
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    Nephron development involves structural changes that enhance kidney function. Increased glomerular basement membrane area and cell membrane surface area correlate with improved sodium and fluid transport capacity during maturation.

    Area of Science:

    • Nephrology
    • Developmental Biology
    • Cell Biology

    Background:

    • The development of the nephron is a complex process involving structural maturation.
    • Understanding the relationship between structural changes and functional capacity is crucial for nephrology.

    Purpose of the Study:

    • To review structural and functional relationships during nephron development.
    • To correlate quantitative structural data with functional changes in the developing nephron.

    Main Methods:

    • Utilized ultrastructural morphometric techniques for quantitative structural analysis.
    • Correlated structural observations with functional parameters of nephron segments.

    Main Results:

    • Glomerular basement membrane area increased 1.7-fold relative to kidney weight.

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  • Suggested increased permeability of the glomerular basement membrane due to enlarged endothelial pores and epithelial slits.
  • Direct correlation found between increased Na and fluid transport capacity and enlarged basal/lateral cell membranes and Na-K-ATPase levels.

    • Conclusions:

    • Structural maturation, including increased glomerular basement membrane area and enhanced cell membrane transport machinery, is essential for functional development of the nephron.
    • These structural adaptations significantly contribute to the maturation of solute and fluid transport in the tubular wall.