Liposarcoma. A review of factors influencing prognosis

Tumors of adipose differentiation demonstrate considerable histologic variability as well as a wide variation in behavior patterns. A variety of clinical, gross, and microscopic features are useful in predicting behavior. Unfortunately, a number of different classification systems for liposarcoma with confusing nomenclature appear in the literature. This paper reviews general features affecting prognosis and presents a summary of the major classification systems. A subclassification of tumors into three grades (high, intermediate, and low) is suggested, based on potential for malignant behavior. Our system of grading may be used to guide the surgeon in the course of therapy. In light of the potential for confusion in identification and classification, good communication between surgeon and pathologist is essential to choice of appropriate therapy and ensuing chances for recurrence or survival.