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Related Experiment Videos

Human monocytes have prothrombin cleaving activity.

N Hogg

    Clinical and Experimental Immunology
    |September 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Human monocytes generate fibrin on their surfaces using thrombin (a clotting protein). This process requires factor II (prothrombin) and suggests monocytes have a prothrombin-cleaving ability crucial for tissue repair.

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    Area of Science:

    • Hematology
    • Cell Biology
    • Biochemistry

    Background:

    • Human monocytes can form fibrin on their surfaces upon plasma exposure.
    • The specific coagulation factors involved in this monocyte-derived fibrin formation are not fully elucidated.

    Purpose of the Study:

    • To investigate the role of coagulation factors in monocyte-induced fibrin formation.
    • To determine if monocytes possess intrinsic procoagulant activity.

    Main Methods:

    • Testing monocyte fibrin formation in various factor-deficient plasmas.
    • Utilizing a thrombin-specific inhibitor (hirudin) to assess thrombin's role.
    • Measuring monocyte prothrombin cleavage over time.

    Main Results:

    Related Experiment Videos

  • Monocyte fibrin formation was impaired only in factor II (prothrombin) deficient plasma.
  • Hirudin inhibited fibrin formation, confirming thrombin's necessity.
  • Monocytes demonstrated an increasing ability to cleave prothrombin to thrombin with incubation time.

    • Conclusions:

    • Human monocytes possess a prothrombin-cleaving activity, generating thrombin necessary for fibrin formation.
    • Thrombin likely plays a significant role in monocyte-mediated wound healing and tissue repair processes.