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Methods for assessing bronchial reactivity.

A J Woolcock, K Yan, C Salome

    European Journal of Respiratory Diseases. Supplement
    |January 1, 1983
    PubMed
    Summary
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    Understanding bronchial hyperreactivity in asthma requires standardized bronchial provocation tests. Histamine and methacholine are effective agents, with FEV1 the preferred measure for distinguishing asthmatic from normal subjects.

    Area of Science:

    • Respiratory Medicine
    • Pulmonology
    • Clinical Physiology

    Background:

    • Bronchial hyperreactivity is a hallmark of asthma.
    • Current studies on bronchial provocation tests lack standardization, hindering comparisons.
    • Diverse methodologies exist for provocation, delivery, measurement, and result reporting.

    Purpose of the Study:

    • To review factors influencing bronchial provocation test responses.
    • To identify optimal agents and methods for assessing bronchial reactivity.
    • To provide recommendations for consistent reporting of test results.

    Main Methods:

    • Review of factors affecting bronchial provocation tests.
    • Analysis of different provoking agents (histamine, methacholine).

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  • Evaluation of lung function tests (FEV1) and result expression.

    • Main Results:

    • Histamine and methacholine are effective in differentiating asthmatic from normal individuals.
    • Provocation technique has minimal impact on test outcomes.
    • Forced expiratory volume in 1 second (FEV1) is the most discriminating lung function test.

    Conclusions:

    • Standardization of bronchial provocation tests is crucial for asthma research.
    • Histamine and methacholine, with FEV1 measurement, offer reliable assessment.
    • Reporting the full dose-response curve, including percent change in FEV1, is recommended.