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Exercise-induced asthma - laboratory observations.

A Bundgaard

    European Journal of Respiratory Diseases. Supplement
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Exercise challenges reveal ventilatory capacity changes in asthma. Inhaled beta-2-agonists offer superior protection against exercise-induced asthma (EIA) compared to injected forms.

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    Area of Science:

    • Pulmonary Medicine
    • Exercise Physiology

    Background:

    • Asthma management involves understanding exercise-induced asthma (EIA).
    • Ventilatory capacity in asthmatics exhibits lability during and after exercise.
    • Assessing EIA requires evaluating both the increase during exercise and the subsequent decrease.

    Purpose of the Study:

    • To emphasize the significance of both the rise and fall in ventilatory capacity for EIA assessment.
    • To investigate the duration of exercise-induced ventilatory lability.
    • To compare the efficacy of inhaled versus intramuscular beta-2-agonists for EIA pretreatment.
    • To establish the equivalence of inhaled and injected terbutaline dosages based on cardiac effects.

    Main Methods:

    • Utilized exercise tests to assess ventilatory capacity changes in adult asthmatics.

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  • Conducted multiple exercise tests within a single day to evaluate sustained lability.
  • Emphasized the necessity of placebo-controlled, double-blind studies for conclusive EIA pretreatment research.
  • Compared the protective effects of inhaled versus intramuscular beta-2-agonists.
  • Assessed cardiac effects to determine terbutaline dosage equivalence.

    • Main Results:

    • Repeated daily exercise tests did not diminish exercise-induced ventilatory lability in adult asthmatics.
    • Inhaled beta-2-agonists demonstrated superior protection against EIA compared to intramuscular administration.
    • Inhaled terbutaline (2.5 mg) showed cardiac effects comparable to approximately 1/4 mg of injected terbutaline.

    Conclusions:

    • Ventilatory capacity lability in asthmatics is a persistent response to exercise.
    • Placebo-controlled, double-blind trials are crucial for evaluating EIA treatments.
    • Inhaled beta-2-agonists are more effective for preventing EIA than intramuscular formulations.
    • Dosage equivalence between inhaled and injected beta-2-agonists can be determined by cardiac effects.