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Nasal reactivity in rhinitis.

P Borum, H Grønborg, S Brofeldt

    European Journal of Respiratory Diseases. Supplement
    |January 1, 1983
    PubMed
    Summary
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    Nasal challenge tests reveal increased reactivity in hay fever and perennial rhinitis patients. This objective method aids in diagnosing rhinitis severity and evaluating new drug treatments.

    Area of Science:

    • Allergy and immunology
    • Rhinology
    • Clinical pharmacology

    Background:

    • Nasal reactivity assessment is crucial for understanding allergic and non-allergic rhinitis.
    • Objective diagnostic tools are needed to evaluate rhinitis severity and treatment efficacy.

    Purpose of the Study:

    • To review data on nasal reactivity to methacholine, histamine, and allergen.
    • To assess reactivity in healthy individuals, common cold patients, perennial rhinitis, and hay fever patients.

    Main Methods:

    • Nasal challenge tests involving spraying agents into the nose.
    • Measurement of sneezes, nasal secretion, and nasal airway resistance over 15 minutes.

    Main Results:

    • A slight increase in nasal reactivity was observed during common colds.

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  • A significant increase in nasal reactivity was noted during hay fever season and in perennial rhinitis.
  • Conclusions:

    • Nasal challenge tests provide objective parameters for diagnosing rhinitis and assessing its severity.
    • These tests can aid in evaluating new drugs, understanding disease mechanisms, and drug actions.