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[Aspects of an interplay between endocrinological and metabolic factors during birth]
The well-known rise of the levels of glucose, lactate, pyruvate, non-esterified free fatty acids (NFFA), glycerol, and ketone bodies during labour cannot be explained only by metabolic pathways. The simultaneous measurement of insulin, cortisol, hGH, and prolactin shows a striking change in secretion, especially of cortisol, after the first half of labour. It is assumed that cortisol plays an important part in the intrapartal metabolic conversions. The correlation cortisol/glucose becomes significant. There is no evidence of the known catabolic effect of cortisol under the conditions of labour, but these is evidence of a reduction of peripheral glucose utilisation. The role of cortisol for the intrapartal metabolic changes is discussed under the aspect of labour progress. The outlines of a very ingenious but also complex interplay between endocrinological and metabolic factors emerge which may provide useful tools for therapeutic use.
The well-known rise of the levels of glucose, lactate, pyruvate, non-esterified free fatty acids (NFFA), glycerol, and ketone bodies during labour cannot be explained only by metabolic pathways. The simultaneous measurement of insulin, cortisol, hGH, and prolactin shows a striking change in secretion, especially of cortisol, after the first half of labour. It is assumed that cortisol plays an important part in the intrapartal metabolic conversions. The correlation cortisol/glucose becomes significant. There is no evidence of the known catabolic effect of cortisol under the conditions of labour, but these is evidence of a reduction of peripheral glucose utilisation. The role of cortisol for the intrapartal metabolic changes is discussed under the aspect of labour progress. The outlines of a very ingenious but also complex interplay between endocrinological and metabolic factors emerge which may provide useful tools for therapeutic use.