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Ceftazidime in the therapy of serious Gram-negative bacillary infections

J C Pottage, P H Karakusis, R M Fliegelman

    The Journal of Antimicrobial Chemotherapy
    |July 1, 1983
    PubMed

    Insights

    Ceftazidime demonstrated a favorable response in 16 of 18 patients with serious Gram-negative infections, including Pseudomonas aeruginosa. This antibiotic shows promise as an alternative to aminoglycosides for treating severe bacterial pathogens.

    Area of Science:

    • Infectious Diseases
    • Clinical Pharmacology
    • Bacteriology

    Background:

    • Serious bacterial infections pose significant treatment challenges.
    • Aminoglycosides are commonly used for Gram-negative infections but can have toxicity.
    • Ceftazidime is a third-generation cephalosporin with broad-spectrum activity.

    Purpose of the Study:

    • To evaluate the efficacy and safety of ceftazidime in treating serious infections.
    • To assess ceftazidime's utility as an alternative to aminoglycosides.
    • To investigate ceftazidime's effectiveness against Pseudomonas aeruginosa.

    Main Methods:

    • A clinical trial involving 18 patients with various serious infections.
    • Isolation and susceptibility testing of 35 bacterial pathogens.
    • Monitoring of patient response and adverse events.

    Main Results:

    • 16 out of 18 evaluable patients showed a favorable response to ceftazidime.
    • Effective treatment was observed in seven of eight patients with Pseudomonas aeruginosa lower respiratory tract infections.
    • Two bacterial isolates were resistant to ceftazidime, necessitating alternative treatment.

    Conclusions:

    • Ceftazidime is a potentially effective alternative to aminoglycosides for serious Gram-negative infections.
    • The drug shows particular promise for infections caused by Pseudomonas aeruginosa.
    • Further investigation is warranted to confirm safety and efficacy in larger patient cohorts.

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