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Related Experiment Videos

A double-blind controlled multicenter trial comparing butriptyline with amitriptyline.

J D Guelfi, J F Dreyfus, M Delcros

    Neuropsychobiology
    |January 1, 1983
    PubMed
    Summary
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    Butriptyline demonstrated superior antidepressant efficacy compared to amitriptyline in primary depressive patients, leading to fewer dropouts and improved symptom scores. Both drugs showed similar safety profiles and effects on other physiological parameters.

    Area of Science:

    • Psychiatry and Pharmacology
    • Clinical Depression Research

    Background:

    • Depression is a prevalent mental health disorder requiring effective pharmacotherapy.
    • Tricyclic antidepressants like amitriptyline are commonly prescribed, but newer agents are continually evaluated for improved efficacy and tolerability.

    Purpose of the Study:

    • To compare the antidepressant efficacy and safety of butriptyline versus amitriptyline in patients with primary depression.
    • To assess the impact of butriptyline and amitriptyline on various depressive symptom clusters and patient dropout rates.

    Main Methods:

    • A randomized, double-blind trial involving 77 primary depressive in-patients aged 18-70 years.
    • Patients received butriptyline or amitriptyline with a flexible dosing schedule up to 150 mg daily, alongside optional nitrazepam or haldol.

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  • Antidepressant efficacy was assessed using multiple rating scales (Hamilton, Overall, BPRS, CGI) and a side effect checklist.

    • Main Results:

    • Butriptyline showed significantly better antidepressant effects than amitriptyline, evidenced by fewer dropouts and superior scores on the Overall Depression Scale (depression, guilt, anxiety, somatization, somatic complaints).
    • The frequency of haldol prescription was significantly lower in the butriptyline group.
    • No significant differences were observed in the overall frequency of side effects, autonomic symptoms, or other physiological parameters (hematological, biochemical, ECG, EEG) between the two drugs.

    Conclusions:

    • Butriptyline offers comparable indications to amitriptyline for treating primary depression.
    • Butriptyline exhibits superior antidepressant efficacy at equivalent dosages compared to amitriptyline.
    • Butriptyline may be a preferred treatment option due to its enhanced effectiveness and reduced need for adjunctive medication like haldol.