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Mass spectrometry: analytical capabilities and potentials.

R G Cooks, K L Busch, G L Glish

    Science (New York, N.Y.)
    |October 21, 1983
    PubMed
    Summary
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    Mass spectrometry has advanced significantly, expanding its mass range and enabling analysis of diverse compounds. These developments enhance its application in biological, environmental, and chemical research, with future trends pointing to wider adoption and novel data analysis.

    Area of Science:

    • Analytical Chemistry
    • Biochemistry
    • Environmental Science

    Background:

    • Mass spectrometry has undergone significant advancements in the past decade.
    • Expanded mass range and novel ionization techniques allow analysis of ionic, nonvolatile compounds.
    • Integration with separation techniques enhances analytical capabilities.

    Purpose of the Study:

    • To review the recent advancements and expanding applications of mass spectrometry.
    • To highlight the utility of mass spectrometry in various scientific disciplines.
    • To discuss emerging trends and future directions in mass spectrometry.

    Main Methods:

    • Review of recent literature and technological developments in mass spectrometry.
    • Integration of mass spectrometry with separation techniques (e.g., chromatography).

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  • Application of advanced ionization methods for diverse sample types.

    • Main Results:

    • Mass spectrometers now cover an extended mass range, enabling analysis of a broader spectrum of compounds.
    • New ionization procedures facilitate the examination of ionic and nonvolatile substances.
    • Mass spectrometry is increasingly used in biological and environmental research, metabolic profiling, and protein structure determination.

    Conclusions:

    • Mass spectrometry's capabilities have expanded, making it a versatile tool across scientific fields.
    • Future trends indicate wider adoption, including multidimensional experiments and advanced instrumentation.
    • Expectation of increased use of non-conventional mass spectral data in future analyses.