Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spectrin: structure, function, and abnormalities.

W Knowles, S L Marchesi, V T Marchesi

    Seminars in Hematology
    |July 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Editorial statement.

    The American journal of pathology·2009
    Same author

    Presentation of the warner-lambert parke-davis award to david a. Clayton and Michael a. Gimbrone, jr: 1982.

    The American journal of pathology·2009
    Same author

    On Baserga's Message.

    The American journal of pathology·2009
    Same author

    Studies on a protein component of Guinea pig erythrocyte membranes.

    The Journal of general physiology·2009
    Same author

    Mumps epididymo-orchitis with prolonged detection of virus in semen and the development of anti-sperm antibodies.

    Journal of medical virology·2004
    Same author

    Primary human herpesvirus-6 and -7 infections, often coinciding, misdiagnosed as measles in children from a tropical region of Brazil.

    Epidemiology and infection·2003
    Same journal

    The many facets of cardiopulmonary complications in sickle cell disease.

    Seminars in hematology·2026
    Same journal

    Clonal hematopoiesis in the setting of sickle cell disease and its relevance to curative therapies.

    Seminars in hematology·2026
    Same journal

    Treatment of myeloproliferative neoplasms: Exploring new horizons of who and when to cytoreduce in patients with polycythemia vera and essential thrombocytosis.

    Seminars in hematology·2026
    Same journal

    Telomeres biology disorders: the past, the present and the future.

    Seminars in hematology·2026
    Same journal

    Cardiovascular complications in patients with myeloproliferative neoplasms: What hematologists need to know.

    Seminars in hematology·2026
    Same journal

    Evolving insights into mitochondrial presence in RBC in sickle cell disease: Red blood cell and reticulocyte pathophysiology, therapeutic strategies, and future directions.

    Seminars in hematology·2026
    See all related articles

    Researchers are uncovering how membrane skeleton proteins, like spectrin, maintain cell integrity. Structural changes in spectrin are linked to disease, offering hope for understanding congenital hemolytic anemias.

    Area of Science:

    • Biochemistry
    • Cell Biology
    • Hematology

    Background:

    • The membrane skeleton is crucial for cellular integrity.
    • Proteins like spectrin play a key role in its structure and function.
    • Understanding these proteins is vital for diagnosing and treating related disorders.

    Purpose of the Study:

    • To investigate the molecular interactions within the membrane skeleton.
    • To develop methods for identifying biochemical variants associated with membrane defects.
    • To explore the relationship between spectrin structure and pathophysiologic states.

    Main Methods:

    • Identification of membrane skeleton proteins.
    • Proposal of a molecular model for spectrin.
    • Development of new analytical procedures for biochemical variant detection.

    Related Experiment Videos

    Main Results:

    • A preliminary molecular model of spectrin has been established.
    • Structural changes in spectrin have been correlated with pathophysiologic states.
    • New analytical methods facilitate the search for relevant biochemical variants.

    Conclusions:

    • Significant progress has been made in understanding membrane skeleton protein interactions.
    • Structural alterations in spectrin are linked to disease states.
    • Further research holds promise for elucidating the pathogenesis of congenital hemolytic anemias.