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"Single-step" orthodontic bonding systems: possible mutagenic potential.

N G Cross, R F Taylor, L J Nunez

American Journal of Orthodontics

|October 1, 1983

Summary

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Two orthodontic resin systems showed mutagenic potential in bacterial tests. Further investigation is needed to assess the safety of direct-bonding materials used in orthodontics.

Area of Science:

Dental Materials Science
Microbiology
Toxicology

Background:

Direct-bonding resin systems are widely used in orthodontics to adhere brackets to tooth enamel.
The potential mutagenicity of these materials has not been extensively studied.
Ensuring the safety of orthodontic materials is crucial for patient health.

Purpose of the Study:

To evaluate the bacterial mutagenicity of commercially available orthodontic direct-bonding resin systems.
To identify specific components within these systems that may pose a mutagenic risk.

Main Methods:

Six direct-bonding resin systems were tested using the Ames test for bacterial mutagenicity.
Components of the resin systems were analyzed.
Dose-response curves were generated for mutagenic components using Salmonella typhimurium strain TA-100 with aqueous and DMSO extracts.

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Main Results:

Components from two of the six tested orthodontic resin systems exhibited positive mutagenicity results.
Mutagenic potential was also detected in resin components applied to orthodontic brackets.
Dose-response relationships were established for these mutagenic components.

Conclusions:

Certain commercially available orthodontic direct-bonding resin systems contain mutagenic components.
The findings highlight the need for careful selection and further toxicological assessment of orthodontic bonding materials.
Future research should focus on developing safer alternatives for orthodontic bracket adhesion.