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Agents with tricyclic structures for treating peptic ulcer disease.
Clinical Pharmacy
|September 1, 1983
Summary
Tricyclic antidepressants and pirenzepine show promise for treating peptic ulcer disease (PUD). These drugs may be effective alternatives for patients unresponsive to standard PUD therapies.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Peptic ulcer disease (PUD) involves an imbalance between acid/pepsin secretion and mucosal resistance.
- Conventional treatments include antacids, H2-receptor antagonists, and sucralfate.
Purpose of the Study:
- To review the use of tricyclic compounds in treating peptic ulcers.
- To assess the efficacy of specific tricyclic agents and pirenzepine in PUD management.
Main Methods:
- Review of existing literature on peptic ulcer disease pathogenesis and treatment.
- Analysis of clinical trial data for trimipramine, doxepin, and pirenzepine in PUD.
Main Results:
- Trimipramine and pirenzepine demonstrated efficacy comparable to cimetidine for short-term duodenal ulcer treatment.
- Limited data suggest effectiveness for gastric ulcers as well.
- Doxepin's efficacy requires further investigation.
Conclusions:
- Tricyclic antidepressants (trimipramine, doxepin) and pirenzepine show potential in PUD treatment.
- These agents may offer benefits for patients refractory to conventional therapies.
- Anticholinergic side effects and sedation may limit their use as first-line treatments.