Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathophysiology of acromegaly.

S Melmed, G D Braunstein, E Horvath

    Endocrine Reviews
    |January 1, 1983
    PubMed
    Summary

    This review classifies acromegaly by cause and pituitary cell type, aiding diagnosis. It proposes a multistage theory for growth hormone cell tumor development, integrating various contributing factors.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Fetomaternal transfusion and pregnancy outcome after cordocentesis.

    Fetal diagnosis and therapy·2001
    Same author

    [Anterior cervical bronchogenic cyst simulating a thyroid lesion. Report of case].

    Revista medica de Chile·2001
    Same author

    Inhibition of evoked glutamate release by the neuroprotective 5-HT(1A) receptor agonist BAY x 3702 in vitro and in vivo.

    Brain research·2001
    Same author

    [Follow-up study of children after functional endoscopic sinus surgery].

    Orvosi hetilap·2000
    Same author

    Pituitary hyperplasia.

    Pituitary·2000
    Same author

    Prolactin-producing pituitary adenoma and carcinoma with neuronal components--a metaplastic lesion.

    Pituitary·2000

    Area of Science:

    • Endocrinology
    • Pathophysiology
    • Oncology

    Background:

    • Acromegaly is a complex endocrine disorder characterized by excess growth hormone (GH).
    • Understanding the diverse etiologies and cellular origins is crucial for effective management.
    • Previous classifications have not fully integrated ultrastructural and cytogenetic data.

    Purpose of the Study:

    • To present a comprehensive classification of acromegaly based on etiology, pituitary ultrastructure, and cytogenesis.
    • To review pathological, clinical, and biochemical evidence for pituitary or hypothalamic origins.
    • To propose a unifying multistage theory for growth hormone cell tumorigenesis.

    Main Methods:

    • Review of existing literature on acromegaly pathophysiology.
    • Classification based on clinical signs, immunoperoxidase techniques, transmission electron microscopy, and immunoelectron microscopy.
    • Analysis of evidence supporting pituitary or hypothalamic origins.

    Main Results:

    • Acromegaly is categorized into distinct pituitary entities (e.g., densely/sparsely granulated adenomas, mixed cell adenomas) and extrapituitary causes (e.g., ectopic GH cell adenoma, GHRF secretion).
    • Includes discussion of GH cell hyperplasia and carcinoma.
    • Pathological, clinical, and biochemical data support diverse etiologies.

    Conclusions:

    • A novel classification integrating ultrastructural and cytogenetic features enhances understanding of acromegaly subtypes.
    • The proposed multistage theory offers a framework for the pathogenesis of GH cell tumors.
    • This comprehensive approach aids in diagnosing and potentially treating acromegaly.

    Related Experiment Videos