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Related Experiment Videos

Mood changes during captopril therapy for hypertension. A double-blind pilot study.

J S Callender, G P Hodsman, M J Hutcheson

    Hypertension (Dallas, Tex. : 1979)
    |September 1, 1983
    PubMed
    Summary

    This pilot study found no euphoriant effect of captopril in hypertensive patients. Captopril treatment lowered blood pressure but did not improve mood, suggesting it does not cause euphoria.

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    Implications of pulse pressure as a predictor of cardiac risk in patients with hypertension.

    Hypertension (Dallas, Tex. : 1979)·2000

    Area of Science:

    • Pharmacology
    • Cardiovascular Medicine
    • Psychiatry

    Background:

    • Hypertension management often involves multiple medications.
    • The potential mood effects of antihypertensive drugs require investigation.

    Purpose of the Study:

    • To evaluate the euphoriant potential of captopril in patients with hypertension.
    • To assess the impact of captopril on mood and psychological state.

    Main Methods:

    • A small, double-blind, placebo-controlled pilot study.
    • Eight hypertensive patients on atenolol and bendrofluazide underwent crossover treatment with captopril or placebo.
    • Psychiatric assessments were conducted throughout the 12-week study.

    Main Results:

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  • Captopril significantly reduced blood pressure, plasma angiotensin II, and increased plasma renin.
  • Mood was slightly but significantly lower during captopril administration.
  • No evidence of a euphoriant effect was observed.

    • Conclusions:

    • Captopril does not appear to have a euphoriant effect in hypertensive patients.
    • The study design is feasible for further research into the psychological effects of antihypertensives.
    • Further refined studies are warranted to explore these findings.