Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sfericase, a novel proteolytic enzyme.

K Yoshida

    International Journal of Clinical Pharmacology, Therapy, and Toxicology
    |September 1, 1983
    PubMed
    Summary

    Sfericase, a novel protease, demonstrates anti-inflammatory effects and reduces sputum viscosity. Clinical studies show its efficacy comparable to serratiopeptidase with fewer side effects, suggesting potential for treating inflammatory conditions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Preparation of a fluorescent derivative of benzoylecgonine, and preliminary studies of its application to the analysis of urine.

    Journal of chromatography·1992
    Same author

    Histochemical demonstration of NADPH-diaphorase activity, a marker for nitric oxide synthase, in neurons of the rat pancreas.

    Neuroscience letters·1992
    Same author

    Pentamidine: a non-peptide GPIIb/IIIa antagonist--in vitro studies on platelets from humans and other species.

    Thrombosis and haemostasis·1992
    Same author

    Unusual cases of benign stricture of the biliary tract.

    The Tokushima journal of experimental medicine·1992
    Same author

    Projections of vertical eye movement-related neurons in the interstitial nucleus of Cajal to the vestibular nucleus in the cat.

    Neuroscience research·1992
    Same author

    Paradoxical bradycardia during exercise and hypoxic exposure. The possible direct effect of hypoxia on sinoatrial node activity in humans.

    Chest·1992

    Area of Science:

    • Enzymology
    • Pharmacology
    • Biochemistry

    Background:

    • Sfericase is a novel protease with endopeptidase activity, derived from Bacillus sphaericus.
    • Existing anti-inflammatory enzymes have varying efficacy and side effect profiles.

    Purpose of the Study:

    • To evaluate the anti-inflammatory properties and therapeutic potential of Sfericase.
    • To compare Sfericase's efficacy and safety against a reference anti-inflammatory drug.

    Main Methods:

    • In vitro and in vivo experimental models for inflammation and sputum viscosity.
    • Clinical trials involving over 900 patients, including double-blind studies against serratiopeptidase.

    Main Results:

    • Sfericase inhibited experimental acute inflammations and reduced sputum viscosity in rabbits.
    • A low molecular fraction of serum from Sfericase-treated animals also exhibited anti-inflammatory effects.
    • Clinical studies indicated Sfericase is as effective as serratiopeptidase with a favorable side effect profile.
    • Sfericase proved effective in chronic inflammatory conditions like sinusitis and bronchopulmonary diseases.

    Conclusions:

    • Sfericase possesses significant anti-inflammatory and mucolytic properties.
    • Its low toxicity and comparable efficacy to serratiopeptidase suggest it is a viable therapeutic option.
    • Sfericase shows promise for managing chronic inflammatory and respiratory conditions with improved safety.

    Related Experiment Videos