Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunomodulation by bromocriptine.

E Nagy, I Berczi, G E Wren

    Immunopharmacology
    |October 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Measurement of the Lambda0b lifetime in the decay lambda0b--> J/psiLambda0 with the D0 detector.

    Physical review letters·2005
    Same author

    Search for supersymmetry with gauge-mediated breaking in diphoton events at D0.

    Physical review letters·2005
    Same author

    The training curriculum in hospital infection control.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2005
    Same author

    In vitro and in vivo percutaneous absorption of topical dosage forms: case studies.

    International journal of pharmaceutics·2005
    Same author

    Use of Etest to assess synergy of antibiotic combinations against clinical isolates of Pseudomonas spp.

    International journal of antimicrobial agents·2005
    Same author

    Search for doubly charged higgs boson pair production in the decay to mu(+)mu(+)mu(-)mu(-) in pp collisions at sqrt[s]=1.96 TeV.

    Physical review letters·2004
    Same journal

    Papers of the 15th International Conference on Kinins. Part III. Nara, Japan, 19-24 October 1998.

    Immunopharmacology·2001
    Same journal

    Papers from the 15th International Conference on Kinins. Part II. Nara, Japan, 19-24 October 1998.

    Immunopharmacology·2001
    Same journal

    Interleukin 2 maintains biologic stability and sterility over prolonged time.

    Immunopharmacology·2000
    Same journal

    Comparative study of lymphocyte-suppressive potency between prednisolone and methylprednisolone in rheumatoid arthritis.

    Immunopharmacology·2000
    Same journal

    Activation of rat splenic macrophage and lymphocyte functions by fumonisin B1.

    Immunopharmacology·2000
    Same journal

    Sublytic complement attack reduces infarct size in rabbit isolated hearts: evidence for C5a-mediated cardioprotection.

    Immunopharmacology·2000
    See all related articles

    Bromocriptine (BRC) suppresses immune responses in rats by lowering prolactin (PRL) and growth hormone (GH) levels. Restoring PRL or GH levels reversed BRC-induced immunosuppression, indicating their crucial role in immunity.

    Area of Science:

    • Immunology
    • Endocrinology
    • Pharmacology

    Background:

    • Ergot alkaloids, like bromocriptine (BRC), are known to interact with various biological systems.
    • The role of hormones such as prolactin (PRL) and growth hormone (GH) in immune function is an area of ongoing research.
    • Understanding drug-induced immune modulation is critical for therapeutic applications.

    Purpose of the Study:

    • To investigate the immunosuppressive effects of bromocriptine (BRC) in a rat model.
    • To determine the role of prolactin (PRL) and growth hormone (GH) in mediating BRC's effects on the immune system.
    • To explore potential therapeutic strategies for reversing drug-induced immunosuppression.

    Main Methods:

    • Rats were treated with bromocriptine (BRC) to assess its impact on various immune reactions, including contact sensitivity, antibody formation, adjuvant arthritis, and experimental allergic encephalitis.

    Related Experiment Videos

  • Serum prolactin (PRL) levels were measured in BRC-treated rats.
  • Immunocompetence in BRC-suppressed rats was evaluated after administration of prolactin (PRL) or growth hormone (GH).
  • The effect of adrenocorticotropic hormone on PRL and GH restoration was examined.

    • Main Results:

    • Bromocriptine (BRC) significantly inhibited multiple immune reactions in rats.
    • BRC treatment led to a substantial decrease in serum prolactin (PRL) levels.
    • Administration of prolactin (PRL) or growth hormone (GH) restored immune function in BRC-suppressed rats.
    • Adrenocorticotropic hormone counteracted the restorative effects of PRL and GH.

    Conclusions:

    • Bromocriptine (BRC) exerts immunosuppressive effects, likely through the inhibition of prolactin (PRL) secretion.
    • Growth hormone (GH) may also play a role in BRC-induced immunosuppression.
    • Prolactin (PRL) and growth hormone (GH) are critical for maintaining immunocompetence and can reverse BRC-mediated immune suppression.