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Aspirin causes tissue insensitivity to insulin in normal man
The Journal of Clinical Endocrinology and Metabolism
|December 1, 1983
Summary
Aspirin enhances insulin release but impairs glucose metabolism in healthy individuals. This study investigated aspirin
Area of Science:
- Endocrinology
- Metabolic Research
- Pharmacology
Background:
- Insulin resistance is a growing health concern.
- Understanding the metabolic effects of common medications like aspirin is crucial.
Purpose of the Study:
- To investigate the impact of aspirin on glucose and insulin metabolism in normal volunteers.
- To determine if aspirin affects insulin sensitivity and glucose disposal.
Main Methods:
- Utilized the hyperglycemic clamp technique in 8 healthy volunteers.
- Administered aspirin (3 g daily for 3 days) prior to testing.
Main Results:
- Aspirin significantly increased both acute (70%) and sustained (45%) insulin release in response to hyperglycemia.
- Despite elevated insulin levels, glucose infusion rates remained unchanged, indicating impaired insulin action (30% decrease in insulin sensitivity).
- Ibuprofen, a similar drug, only affected acute insulin release.
Conclusions:
- Aspirin enhances pancreatic beta-cell responsiveness to glucose.
- Aspirin impairs glucose metabolism in insulin-sensitive tissues, suggesting reduced insulin sensitivity.
- The precise mechanism, potentially involving prostaglandin synthesis inhibition, requires further investigation.