Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Atherosclerosis: fundamental mechanisms].

B Jacotot

    Pathologie-Biologie
    |September 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Atherosclerosis develops slowly and silently over years, posing a severe risk of sudden, life-threatening complications like arterial narrowing and thrombosis. Understanding its complex pathogenesis is crucial for managing this widespread cardiovascular disease.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Role of diet in cardiovascular prevention].

    Annales de medecine interne·2001
    Same author

    Effect of an alpha-blocker (Nicergoline) and of a beta-blocker (Acebutolol) on the in vitro biosynthesis of vascular extracellular matrix.

    Pathologie-biologie·2001
    Same author

    Autosomal dominant type IIa hypercholesterolemia: evaluation of the respective contributions of LDLR and APOB gene defects as well as a third major group of defects.

    European journal of human genetics : EJHG·2000
    Same author

    [The hyperlipidemias. What remains of the Fredrickson classification?].

    Presse medicale (Paris, France : 1983)·1999
    Same author

    Plasma lipoprotein distribution and lipid transfer activities in patients with type IIb hyperlipidemia treated with simvastatin.

    Atherosclerosis·1999
    Same author

    Abnormal capacity to induce cholesterol efflux and a new LpA-I pre-beta particle in type 2 diabetic patients.

    Clinica chimica acta; international journal of clinical chemistry·1999
    Same journal

    Pathologie-biologie·2020
    Same journal

    Antibacterial and antibiofilm activities of Laurus nobilis L. essential oil against Staphylococcus aureus strains associated with oral infections.

    Pathologie-biologie·2015
    Same journal

    [Not Available].

    Pathologie-biologie·2015
    Same journal

    Oxidative damage and histopathological changes in lung of rat chronically exposed to nicotine alone or associated to ethanol.

    Pathologie-biologie·2015
    Same journal

    Biological diagnosis of diabetes mellitus.

    Pathologie-biologie·2015
    Same journal

    Association of CagPAI integrity with severeness of Helicobacter pylori infection in patients with gastritis.

    Pathologie-biologie·2015
    See all related articles

    Area of Science:

    • Cardiovascular Medicine
    • Pathology
    • Biochemistry

    Context:

    • Atheromatous lesions evolve slowly over years, often remaining asymptomatic until critical complications arise.
    • Known macroscopic and histologic features of atherosclerotic lesions, alongside arterial component composition, are well-established.
    • The pathogenesis of atherosclerosis remains incompletely understood, suggesting multiple initiating causes and common underlying mechanisms.

    Purpose:

    • To review the current understanding of atheromatous lesion evolution and its associated complications.
    • To highlight the known aspects of atherosclerotic lesions, including their composition.
    • To emphasize the remaining mysteries in atherosclerosis pathogenesis and the emerging view of multifactorial origins.

    Summary:

    Related Experiment Videos

  • Atherosclerosis is a slow, silent disease characterized by lesion development over years.
  • Complications such as arterial lumen reduction, thrombosis, embolism, and aneurysms pose significant risks.
  • While lesion morphology and composition are known, the precise pathogenesis involving numerous contributing factors and common mechanisms is an active area of research.

    • Impact:

    • Improved understanding of atherosclerosis pathogenesis can lead to better diagnostic and therapeutic strategies.
    • Identifying common mechanisms underlying multifactorial causes may reveal novel therapeutic targets.
    • Addressing the silent progression and sudden complications of atherosclerosis is vital for improving patient prognosis and reducing mortality.