Verrucous carcinoma of the vagina

The case histories of three women with verrucous carcinoma of the vagina are presented. Verrucous carcinoma, in the female genital tract as elsewhere, is a relentlessly growing, destructive, but generally nonmetastasizing neoplasm of stratified squamous epithelium with a characteristic gross and microscopic appearance. It should be recognized and segregated from the usual type of squamous carcinoma so that appropriate therapy can be administered. Surgical excision is the treatment of choice. Radiotherapy is usually contraindicated. Two of the patients described here were treated by surgery alone with good results. The other received radiation only and died within a year with persistent disease.