Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intestinal blood flow and oxygen consumption.

R H Gallavan, J D Fondacaro, E D Jacobson

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
    |October 1, 1983
    PubMed
    Summary

    Intestinal oxygen consumption increases with blood flow, not directly due to prostacyclin. This study shows oxygen use in the gut is flow-dependent, impacting metabolism research.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Update on the Center for Devices and Radiological Health.

    Food and drug law journal·2002
    Same author

    Potential estrogenic and antiestrogenic activity of the cyclic siloxane octamethylcyclotetrasiloxane (D4) and the linear siloxane hexamethyldisiloxane (HMDS) in immature rats using the uterotrophic assay.

    Toxicological sciences : an official journal of the Society of Toxicology·2001
    Same author

    Repeated inhalation exposure to octamethylcyclotetrasiloxane produces hepatomegaly, transient hepatic hyperplasia, and sustained hypertrophy in female Fischer 344 rats in a manner similar to phenobarbital.

    Toxicology and applied pharmacology·2001
    Same author

    Physiological modeling reveals novel pharmacokinetic behavior for inhaled octamethylcyclotetrasiloxane in rats.

    Toxicological sciences : an official journal of the Society of Toxicology·2001
    Same author

    Leukocyte reduction filters may cause hypotension.

    Clinical journal of oncology nursing·2000
    Same author

    Hypotension and bedside leukocyte reduction filters.

    International journal of trauma nursing·2000

    Area of Science:

    • Physiology
    • Gastroenterology
    • Metabolism

    Background:

    • Intestinal oxygen consumption is crucial for gut function.
    • Understanding factors influencing intestinal oxygen use is vital for metabolic research.

    Purpose of the Study:

    • To investigate the relationship between intestinal blood flow and oxygen consumption.
    • To determine if prostacyclin directly affects intestinal metabolism or indirectly via blood flow changes.

    Main Methods:

    • Pharmacological induction of increased intestinal blood flow using prostacyclin.
    • Mechanical induction of increased intestinal blood flow.
    • Measurement of intestinal blood flow and oxygen consumption.

    Main Results:

    • Prostacyclin infusion increased both intestinal blood flow and oxygen consumption.
    • The increase in oxygen consumption correlated with the rise in blood flow.
    • Mechanically increasing blood flow also elevated oxygen consumption, supporting the flow-dependency hypothesis.

    Conclusions:

    • Intestinal oxygen consumption is primarily dependent on blood flow.
    • Prostacyclin's effect on oxygen consumption is likely mediated by increased blood flow, not direct metabolic action.
    • Gut metabolism is flow-limited across a broad spectrum of blood flow rates.

    Related Experiment Videos