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Renal function study with 111In-DTPA--in comparison with 99mTc-DTPA
Radioisotopes
|April 1, 1983
Summary
Technetium-99m-diethylene-triamine-penta-acetic acid (DTPA) and Indium-111-DTPA show strong correlation in renal function assessment. Both isotopes provide comparable clearance values and renogram parameters, indicating their utility in evaluating kidney function.
Area of Science:
- Nuclear Medicine
- Radiopharmacology
- Renal Physiology
Background:
- Renal imaging utilizes radiopharmaceuticals to assess kidney function.
- Technetium-99m-diethylene-triamine-penta-acetic acid (99mTc-DTPA) and Indium-111-DTPA (111In-DTPA) are commonly used agents.
- Comparative analysis is crucial for optimizing diagnostic protocols.
Purpose of the Study:
- To compare the diagnostic efficacy of 99mTc-DTPA and 111In-DTPA in assessing renal function.
- To evaluate the correlation between renogram parameters and clearance values obtained with both isotopes.
Main Methods:
- Simultaneous injection of 99mTc-DTPA and 111In-DTPA in 21 patients with varying renal function.
- Acquisition of scintiphoto images, camera data renograms, and plasma clearance values.
- Statistical analysis to determine correlation coefficients for key parameters.
Main Results:
- 111In-DTPA scintiphoto images were of inferior quality compared to 99mTc-DTPA.
- High correlation coefficients (r=0.98-0.99) were observed between 99mTc-DTPA and 111In-DTPA for T peak, T3/4, excretion ratios, and clearance values.
- Renogram parameters and clearance values showed excellent agreement between the two isotopes.
Conclusions:
- Despite lower image quality, 111In-DTPA provides reliable renal function assessment comparable to 99mTc-DTPA.
- Both radiotracers can be used interchangeably for quantitative renal function evaluation.
- The strong correlation supports the use of either isotope for renography and clearance studies.