Antifungal action of rifampin

Rifampin and amphotericin B were found to be synergistic in vitro against Saccharomyces cerevisiae, Histoplasma capsulatum, and several species of Aspergillus, The uptake of rifampin by the fungi was increased in the presence of amphotericin B, and this increase probably formed the basis for the synergistic activity observed. In vivo, the combination proved more effective than either drug alone against experimental infections with H. capsulatum, Blastomyces dermatitidis, and Aspergillus species.