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Invasive enteric pathogens.

S B Formal, T L Hale, P J Sansonetti

Reviews of Infectious Diseases

|September 1, 1983

Summary

This summary is machine-generated.

Invasive enteric pathogens like Salmonella and Shigella cause intestinal infections. Plasmids, which are extrachromosomal DNA, are crucial for the virulence of these bacteria.

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Area of Science:

Microbiology
Pathogen Biology
Genetics

Background:

Invasive enteric pathogens, including Salmonella and Shigella, infect the intestinal epithelium.
Salmonellae can cause systemic illness or localized inflammation (gastroenteritis).
Shigellae invade the colon, leading to inflammation, ulceration, and bacillary dysentery.

Purpose of the Study:

To investigate the genetic basis of virulence in invasive enteric pathogens.
To identify key genetic elements required for pathogen invasion and disease manifestation.

Main Methods:

Genetic analysis of Salmonella and Shigella species.
Examination of the role of extrachromosomal elements (plasmids) and chromosomal regions in virulence.

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Main Results:

Extrachromosomal elements (plasmids) are essential for the full virulence of Salmonella typhimurium, Yersinia enterocolitica, Shigella sonnei, and Shigella flexneri.
In Shigella flexneri, additional chromosomal regions are also required for virulence.

Conclusions:

Plasmids play a critical role in the virulence of several invasive enteric pathogens.
Both plasmid-borne and chromosomal genes contribute to the pathogenicity of species like Shigella flexneri.