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Related Experiment Videos

The diffuse endocrine system in cystic fibrosis.

K D Buchanan, J I Kerr, C F Johnston

    Scandinavian Journal of Gastroenterology. Supplement
    |January 1, 1983
    PubMed
    Summary

    Cystic Fibrosis (CF) involves the diffuse endocrine system (DES), affecting hormone release and potentially linked to malabsorption. Increased vasoactive intestinal polypeptide-like immunoreactive (VIP-LI) cells suggest paracrine roles in CF.

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    Area of Science:

    • Endocrinology
    • Gastroenterology
    • Pulmonology

    Background:

    • Cystic Fibrosis (CF) is a genetic disorder affecting multiple organ systems.
    • The diffuse endocrine system (DES) role in CF pathophysiology is not fully understood.
    • Hormonal imbalances and malabsorption are frequently observed in CF patients.

    Purpose of the Study:

    • To review the involvement of the diffuse endocrine system (DES) in Cystic Fibrosis (CF).
    • To explore the relationship between malabsorption, intestinal factors, and hormonal deficiencies in CF.
    • To investigate the significance of Vasoactive intestinal polypeptide-like immunoreactive (VIP-LI) cells in CF.

    Main Methods:

    • Review of existing literature on CF pathology, aetiology, and clinical features.

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  • Analysis of hormonal responses (insulin, gastric inhibitory polypeptide - GIP) to different meal types.
  • Histological examination of intestinal tissue for VIP-LI and mucous cells.

    • Main Results:

    • Carbohydrate intolerance is common in CF, with deficient islet hormone and GIP release.
    • Elemental meals improved post-prandial insulin and GIP responses, indicating malabsorption influence.
    • Increased VIP-LI cells were observed in CF, closely associated with mucous cells.

    Conclusions:

    • The diffuse endocrine system (DES) is implicated in Cystic Fibrosis (CF), potentially secondary to malabsorption.
    • Intestinal factors and malabsorption may contribute to impaired hormone release in CF.
    • The paracrine relationship between VIP-LI and mucous cells warrants further investigation for CF diagnosis and management.