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Related Experiment Videos

Cerebromedullospinal disconnection after intraventricular methotrexate.

A N Krutchik, G R Blumenschein, C K Tashima

    Southern Medical Journal
    |April 1, 1978
    PubMed
    Summary

    A rare case of locked-in syndrome, a severe neurological condition, was observed following intraventricular methotrexate treatment. This unusual complication is thought to stem from ventral pontine infarction.

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    Area of Science:

    • Neurology
    • Neuro-oncology
    • Pharmacology

    Background:

    • Intraventricular methotrexate is a chemotherapy agent used for central nervous system cancers.
    • Complications of intraventricular chemotherapy can include neurological deficits.

    Observation:

    • A patient developed cerebromedullospinal disconnection, also known as locked-in syndrome.
    • This syndrome occurred subsequent to the administration of intraventricular methotrexate.

    Findings:

    • The case presents an unusual complication of intraventricular methotrexate instillation.
    • Ventral pontine infarction is the suspected cause of the observed locked-in syndrome.

    Implications:

    • This case highlights a rare but serious potential adverse effect of intraventricular methotrexate.

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  • Understanding this complication may inform treatment strategies and patient monitoring in neuro-oncology.