Related Experiment Video
Updated: Sep 7, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
Aspirin: plasma concentration and effects
Abstract:
The antithrombotic effect of acetylsalicylic acid is intimately linked to its reactivity. The labile acetyl moiety irreversibly acetylates not only cyclo-oxygenase, but other biological components. The presence off ubiquitous esterases leads to the rapid disappearance of ASA from the body. The pharmacokinetics of ASA is affected by the dosage form used and the presence of food. Despite the absence of a definable relationship between plasma ASA levels and response, recent data would suggest a dose of about 0.5 mg/kg/day adequately suppresses platelet aggregation without affecting prostacyclin formation.
Related Concept Videos
Time Course of Drug Effect
Drug Distribution: Plasma Protein Binding
Drug Concentration Versus Time Correlation
Two pivotal parameters are the minimum effective concentration (MEC) and the minimum toxic concentration (MTC). The MEC is the lowest drug...
Factors Affecting Protein-Drug Binding: Drug Interactions
Displacement interactions can have varying outcomes, ranging from toxicity to virtually...
Hepatic Drug Clearance: Effect of Protein Binding
For low-extraction-ratio drugs that are less than 80% protein-bound, minor changes in protein binding...
Drug toxicity: Drug–Drug Interaction

