[Morphologic changes in the myelin-poor hypothalamus in involution and senescence in relation to the involution of...

Caused by diseases or in senescence gonadal atrophy entails morphological alterations in certain hypothalamic neurons particularly in the arcuate and subventricular nucleus. In consequence of an inefficacious and perpetual feedback these cells develop phenomenons of activation on their nucleoli. The continuous nuclear-nucleolar changes are present down to the senium and likely must be seen in relation to the persistently elevated gonadotropin levels in the old age.--Another remarkable finding is the hypertrophy of the subventricular nucleus (Sheehan and Kovacs).