Related Experiment Video
Updated: Jul 9, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
Very low calorie diets: their efficacy, safety, and future
Very low calorie diets achieve significant weight loss for obesity. High-quality protein diets are safe for short-term use under medical supervision, but long-term weight maintenance remains a challenge.
Area of Science:
- Nutrition Science
- Obesity Research
- Metabolic Health
Background:
- Very low calorie diets (VLCDs) are used for moderate to severe obesity.
- Historical context traces VLCD development from fasting research.
- Past
- liquid protein
- diets had significant safety concerns.
Purpose of the Study:
- Review the development and safety of VLCDs.
- Examine protein requirements for positive nitrogen balance.
- Discuss factors influencing VLCD efficacy and safety.
Main Methods:
- Literature review of VLCD development and research.
- Analysis of data on protein needs and nitrogen balance.
- Examination of clinical course and patient selection for VLCDs.
Main Results:
- VLCDs yield average weight losses of 20 kg in 12 weeks.
- High-quality protein VLCDs appear safe for up to 3 months with medical supervision.
- No diet-related fatalities reported in over 10,000 cases, supported by Holter monitoring.
Conclusions:
- VLCDs are effective for rapid weight loss in obesity.
- Careful patient selection and medical supervision are crucial for VLCD safety.
- Long-term weight maintenance after VLCD treatment is the primary unresolved issue.
More Related Videos
09:10Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
Published on: November 1, 2019
06:28A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
Published on: April 28, 2023
Related Concept Videos
Lipids: Dietary Sources and Requirements
Metabolic States of the Body: Fasting and Starvation
Energy Balance
Regulation of Food Intake
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Chronic Kidney Disease III: Interprofessional Care