[Comparison of the activity of cefaclor with amoxicillin, erythromycin and doxycycline in an in vitro model]

Bactericidal antibiotics like cefaclor and amoxicillin do have a better and prolonged effect on the reduction of the viable cellcount than bacteriostatic ones like erythromycin and doxycyclin, as has been demonstrated in the in vitro model. The influence of the production of beta-lactamases on the kill-kinetics could be studied in this model. While amoxillin became ineffective by the production of beta-lactamases of E. coli and S. aureus the activity of cefaclor was generally maintained. Only a marginal destruction of the drug by the enzymes was observed.