Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renin in the arterial wall.

J D Swales, M Loudon, R F Bing

    Clinical and Experimental Hypertension. Part A, Theory and Practice
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Lowering of Central Aortic Blood Pressure-Not All Antihypertensive Agents Are Created Equal: Differential Impact of Blood Pressure-Lowering Drugs on Central Aortic Pressure and Clinical Outcomes: Principal Results of the Conduit Artery Function Evaluation (CAFE) Study. Circulation 113: 1213-1225, 2006.

    Journal of the American Society of Nephrology : JASN·2023
    Same author

    Reply to: Extralevator abdomino-perineal excision (ELAPE) or abdomino-sacral amputation of the rectum (ASAR): revitalised approach for low rectal carcinoma described by Tadeusz Koszarowski in the 50s.

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2014
    Same author

    Analysis of outcome using a levator sparing technique of abdominoperineal excision of rectum and anus. Cylindrical ELAPE is not necessary in all patients.

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2013
    Same author

    The Journal: tradition and change.

    Journal of the Royal Society of Medicine·2010
    Same author

    Issues of the day: what are they?

    Journal of the Royal Society of Medicine·2010
    Same author

    The new Journal-progress report.

    Journal of the Royal Society of Medicine·2010

    Vascular walls possess renin-like activity, distinct from plasma renin. This aortic activity, not plasma levels, better predicts blood pressure responses, suggesting its crucial role in blood pressure regulation.

    Area of Science:

    • Biochemistry
    • Physiology
    • Cardiovascular Research

    Background:

    • Rat aortic wall homogenates exhibit renin-like activity, generating angiotensin I from plasma.
    • This activity involves proteolytic enzymes and shows different pH optima compared to renal renin.

    Purpose of the Study:

    • To determine if aortic renin-like activity originates from plasma renin.
    • To investigate the role of vascular renin-like activity in blood pressure control.

    Main Methods:

    • Altering plasma and aortic renin levels via bilateral nephrectomy and salt intake modulation.
    • Studying four models of hypertension: Goldblatt 2-kidney 1-clip (early and chronic), DOC-salt, and spontaneous hypertension.
    • Comparing pressor responses to injected renin with plasma and aortic renin activity levels.

    Related Experiment Videos

    Main Results:

    • Aortic and plasma renin-like activities showed parallel changes under steady-state conditions.
    • Acute renin injection revealed a shorter half-life for plasma renin than aortic renin.
    • Pressor response to renin correlated more strongly with aortic renin activity than plasma renin activity.

    Conclusions:

    • Renin uptake by the arterial wall is a significant determinant of blood pressure.
    • Evidence does not support local renin accumulation causing hypertension when plasma renin is normal or low.