Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytoplasmic modification of nuclear gene expression.

J W Shay

    Molecular and Cellular Biochemistry
    |January 1, 1983
    PubMed
    Summary

    Mammalian cell cytoplasm can autonomously regulate gene expression. Cytoplasmic factors may suppress tumor formation, potentially through DNA methylation changes influencing nuclear gene activity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Characterization of human isogenic epithelial cell lines as a relevant tool to study colon carcinogenesis and interactions between genes and environment.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
    Same author

    The longitudinal behavioral effects of acute exposure to galactic cosmic radiation in female C57BL/6J mice: implications for deep space missions, female crews, and potential antioxidant countermeasures.

    bioRxiv : the preprint server for biology·2024
    Same author

    Retraction Note: OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation.

    Cell death & disease·2022
    Same author

    Differential Kras<sup>V12</sup> protein levels control a switch regulating lung cancer cell morphology and motility.

    Convergent science physical oncology·2017
    Same author

    ICRP Publication 131: Stem cell biology with respect to carcinogenesis aspects of radiological protection.

    Annals of the ICRP·2016
    Same author

    ICRP Publication 131: Stem Cell Biology with Respect to Carcinogenesis Aspects of Radiological Protection.

    Annals of the ICRP·2015

    Area of Science:

    • Cell Biology
    • Molecular Biology
    • Genetics

    Background:

    • The cytoplasm of mammalian cells exhibits a degree of autonomy.
    • Cytoplasmic components can influence nuclear gene expression.
    • Tumorigenesis is a complex process involving genetic and epigenetic alterations.

    Purpose of the Study:

    • To review the autonomous nature of mammalian cell cytoplasm.
    • To explore how cytoplasm modifies nuclear gene expression.
    • To discuss the role of cytoplasmic factors in suppressing tumorigenicity.

    Main Methods:

    • Literature review of existing research.
    • Analysis of studies on cytoplasmic influence on gene expression.
    • Examination of proposed mechanisms for cytoplasmic control.

    Main Results:

    • Evidence supporting cytoplasmic autonomy in mammalian cells.
    • Demonstration of cytoplasmic modification of nuclear gene expression.
    • Discussion of cytoplasmic suppression of tumorigenicity as a potential biological phenomenon.

    Conclusions:

    • Cytoplasmic factors play a significant role in regulating nuclear gene expression.
    • Alterations in DNA methylation patterns are proposed as a key mechanism for this cytoplasmic influence.
    • Further research is warranted to fully elucidate these cytoplasmic regulatory roles.

    Related Experiment Videos