Related Experiment Video

Updated: May 2, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 10, 2011

22.2K

Staphylococcus epidermidis infections

F D Lowy, S M Hammer

    Annals of Internal Medicine
    |December 1, 1983
    PubMed

    Insights

    Staphylococcus epidermidis causes difficult-to-diagnose prosthetic device infections. Effective treatment requires combination antibiotics and often prosthetic device removal for successful outcomes.

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Medical Devices

    Background:

    • Staphylococcus epidermidis is a common skin and hospital-environment organism.
    • It is a primary cause of infections linked to prosthetic devices.
    • These infections are often indolent, clinically silent, and misdiagnosed as contaminants.

    Purpose of the Study:

    • To highlight the diagnostic and therapeutic challenges of Staphylococcus epidermidis prosthetic device infections.
    • To discuss antibiotic susceptibility testing limitations and effective treatment strategies.

    Main Methods:

    • Review of clinical presentation and diagnostic difficulties.
    • Analysis of antibiotic susceptibility patterns and treatment outcomes.
    • Evaluation of the role of prosthetic device removal in therapy.

    Main Results:

    • Variable and resistant antibiotic susceptibility complicates treatment selection.
    • In-vitro beta-lactam sensitivity testing shows uncertain correlation with clinical efficacy.
    • Combination therapy (Vancomycin with Rifampin/Gentamicin) is recommended for empiric treatment.

    Conclusions:

    • Staphylococcus epidermidis prosthetic device infections pose significant diagnostic and therapeutic challenges.
    • Effective management necessitates a combination of appropriate antibiotic therapy and often surgical removal of the infected device.
    • Accurate diagnosis and tailored treatment are crucial for successful patient outcomes.

    More Related Videos

    A Zebrafish Embryo Model for In Vivo Visualization and Intravital Analysis of Biomaterial-associated Staphylococcus aureus Infection10:04

    A Zebrafish Embryo Model for In Vivo Visualization and Intravital Analysis of Biomaterial-associated Staphylococcus aureus Infection

    Published on: January 7, 2019

    6.5K
    Improved Enzyme Protection Assay to Study Staphylococcus aureus Internalization and Intracellular Efficacy of Antimicrobial Compounds06:36

    Improved Enzyme Protection Assay to Study Staphylococcus aureus Internalization and Intracellular Efficacy of Antimicrobial Compounds

    Published on: September 8, 2021

    6.7K

    Related Concept Videos

    Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

    Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

    Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
    HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
    5.7K
    Clinical Applications of Epidermal Stem Cells01:19

    Clinical Applications of Epidermal Stem Cells

    Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
    2.4K
    Skin Diseases and Disorders01:23

    Skin Diseases and Disorders

    Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
    Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
    5.4K
    The Skin Microbiota01:27

    The Skin Microbiota

    The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
    123
    Staphylococcal Skin Infections01:29

    Staphylococcal Skin Infections

    Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
    143
    Clinical Significance of Antibiotic Resistance01:25

    Clinical Significance of Antibiotic Resistance

    Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
    90