Mazindol in the control of micturition

The appetite suppressant mazindol has been compared with a placebo in the control of incontinence in a double-blind cross-over trial. Twenty-five patients were entered; 4 were withdrawn for protocol violations. The underlying diagnoses were determined; 19 had stable detrusors and 6 unstable. Seventeen patients made a complete response to mazindol for a 68% overall response rate.