Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vasoactive intestinal polypeptide in the normal and unstable bladder.

J Gu, J M Restorick, M A Blank

    British Journal of Urology
    |December 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A new urethral catheterisation device (UCD) to manage difficult urethral catheterisation.

    World journal of urology·2018
    Same author

    Lichen sclerosus associated with perineal urethrostomy.

    The British journal of dermatology·2013
    Same author

    Words of wisdom. Re: Outcome of dorsal buccal graft urethroplasty for recurrent urethral strictures.

    European urology·2009
    Same author

    ["FlowSecure" artificial urinary sphincter: a new adjustable artificial urinary sphincter concept with conditional occlusion for stress urinary incontinence].

    Actas urologicas espanolas·2007
    Same author

    ["Flowsecure" artificial urinary sphincter: a new adjustable artificial urinary sphincter concept with conditional occlusion for stress urinary incontinence].

    Actas urologicas espanolas·2007
    Same author

    [The role of low urethral mucosal and submucosal blood perfusion in patients with artificial urinary sphincters].

    Actas urologicas espanolas·2007

    Idiopathic detrusor instability may involve vasoactive intestinal polypeptide (VIP) nerves. Studies show significantly reduced VIP concentration and nerve numbers in unstable bladders, suggesting a role in the disorder.

    Area of Science:

    • Urology
    • Neuroscience
    • Gastroenterology

    Background:

    • Idiopathic detrusor instability (IDI) is a common urological condition.
    • The role of autonomic nerves, specifically those containing vasoactive intestinal polypeptide (VIP), in IDI is not well understood.

    Purpose of the Study:

    • To investigate the involvement of VIP-containing autonomic nerves in idiopathic detrusor instability.
    • To quantify VIP concentration and VIP-immunoreactive nerve distribution in bladder biopsies from patients with and without IDI.

    Main Methods:

    • Immunocytochemistry and radioimmunoassay were used to analyze 20 bladder biopsy specimens from patients with IDI and 20 from controls.
    • Specific antibodies against VIP were employed for precise detection and quantification.

    Related Experiment Videos

    Main Results:

    • Bladder tissue from patients with IDI showed a significant reduction in VIP concentration (7.62 ± 1.84 pmol/g) compared to controls (36.52 ± 4.8 pmol/g).
    • A marked decrease in VIP-immunoreactive nerves was observed in all bladder layers, most notably in the muscle layer, of patients with IDI.

    Conclusions:

    • Reduced VIP-containing nerves and lower VIP levels in the bladder may be implicated in the pathophysiology of idiopathic detrusor instability.
    • These findings offer potential insights into the mechanisms underlying IDI and suggest VIP as a target for future research.