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[Therapeutic efficacy of KS-R1, an ampicillin suppository, against experimental infections in mice]
Abstract:
In experimental infections induced with S. aureus, S. pneumoniae, E. coli, K. pneumoniae, P. mirabilis and H. influenzae in mice, the therapeutic efficacies of ampicillin (ABPC) after its rectal administration were compared with those obtained after its oral and subcutaneous administration, and the following results were obtained. Generally, in experimental intraperitoneal infections of mice, the effects of ABPC after rectal administration were inferior to those after subcutaneous administration and superior to those after oral administration. In experimentally induced intraperitoneal and urinary tract infection of E. coli KC-14, similar results were obtained. The plasma levels were reflected as the difference between various administration in the therapeutic efficacies observed with ABPC.
Insights
Rectal administration of ampicillin (ABPC) showed better therapeutic efficacy than oral but was inferior to subcutaneous routes in mouse infection models. Plasma levels correlated with observed differences in treatment effectiveness.
Area of Science:
- Pharmacology
- Microbiology
- Infectious Diseases
Background:
- Bacterial infections pose significant therapeutic challenges.
- Ampicillin (ABPC) is a widely used antibiotic.
- Optimizing antibiotic administration routes is crucial for effective treatment.
Purpose of the Study:
- To compare the therapeutic efficacy of ampicillin (ABPC) via rectal, oral, and subcutaneous administration.
- To evaluate the impact of administration route on ABPC's effectiveness against various bacterial infections in mice.
- To correlate plasma drug levels with therapeutic outcomes.
Main Methods:
- Induction of experimental infections in mice using Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and Haemophilus influenzae.
- Administration of ampicillin (ABPC) through rectal, oral, and subcutaneous routes.
- Assessment of therapeutic efficacy and measurement of plasma drug concentrations.
Main Results:
- Rectal administration of ABPC demonstrated superior therapeutic effects compared to oral administration.
- Subcutaneous administration of ABPC yielded better results than rectal administration.
- Similar efficacy trends were observed in both intraperitoneal and urinary tract infection models.
Conclusions:
- Rectal administration of ampicillin offers an alternative route with moderate efficacy.
- Therapeutic outcomes are significantly influenced by the route of ampicillin administration.
- Plasma drug concentrations are a key determinant of ampicillin's efficacy across different administration routes.