Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hydroxyurea and infected stones.

M J Smith

    Urology
    |March 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Hydroxyurea, an enzyme inhibitor, shows promise in managing struvite stones by helping patients acidify urine. This experimental study suggests hydroxyurea may be a valuable treatment option for struvite stones.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Functional characterization of L-selectin ligands on human neutrophils and leukemia cell lines: evidence for mucinlike ligand activity distinct from P-selectin glycoprotein ligand-1.

    Blood·1998
    Same author

    An equation to QA check the total treatment time for single-catheter HDR brachytherapy.

    International journal of radiation oncology, biology, physics·1998
    Same author

    Inhibition of thromboxane synthesis attenuates insulin hypertension in rats.

    American journal of hypertension·1997
    Same author

    The effect of blockade of kappa-opioid receptors in the medial preoptic area on the luteinizing hormone surge in the proestrous rat.

    Brain research·1997
    Same author

    Significance of WBC differential when leukopenia is induced by 6-MP for IBD.

    Gastroenterology·1997
    Same author

    Diminished insulin and glucagon secretory responses to arginine in nondiabetic subjects with a mutation in the hepatocyte nuclear factor-4alpha/MODY1 gene.

    Diabetes·1997
    Same journal

    Editorial Comment on "A Histopathologic Assessment of Prostate Ductal Anatomy in Relation to Micro-Ultrasound".

    Urology·2026
    Same journal

    Same-Day Discharge Following Multiport Robot-Assisted Simple Prostatectomy: A Prospective Feasibility Study of Outcomes, Costs, and Post-Discharge Healthcare Utilization.

    Urology·2026
    Same journal

    Extended versus Standard Lymph Node Dissection at the Time of Radical Cystectomy for Bladder Cancer.

    Urology·2026
    Same journal

    Intractable Epistaxis and Severe Hypertension in a Young Woman.

    Urology·2026
    Same journal

    A 53-Year-Old Man with Elevated PSA and a Cystic Pelvic Lesion.

    Urology·2026
    Same journal

    Low-Grade, Papillary Bladder Tumors A plea for in-office fulguration.

    Urology·2026
    See all related articles

    Area of Science:

    • Urology
    • Nephrology
    • Microbiology

    Background:

    • Struvite stone formation is linked to urease-producing bacteria in urine.
    • Hydroxamic acids are known inhibitors of the urease enzyme.
    • Hydroxyurea is a hydroxamic acid with potential urease-inhibiting properties.

    Purpose of the Study:

    • To evaluate the efficacy and safety of hydroxyurea in patients with struvite stones.
    • To assess hydroxyurea's effect on urine acidification and infection control.
    • To determine if hydroxyurea can reduce the size of existing struvite calculi.

    Main Methods:

    • A study involving 21 patients with struvite stones treated with hydroxyurea (500 mg daily).
    • Treatment duration was three months or longer, with some patients observed for one year.

    Related Experiment Videos

  • Concurrent treatment with nitrofurantoin was administered to assess combined efficacy.

    • Main Results:

    • Most patients could acidify their urine despite persistent urinary infections.
    • After three months, 78.6% of patients receiving nitrofurantoin and hydroxyurea had sterile urine.
    • No toxic effects were observed in patients over a one-year follow-up period.
    • Three patients experienced a reduction in the size of their retained struvite stones.

    Conclusions:

    • Hydroxyurea demonstrates potential as a therapeutic agent for managing struvite stones.
    • The drug appears effective in controlling urinary infections and promoting urine acidification.
    • Further research is warranted to confirm the utility of hydroxyurea in struvite stone management.