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Teratogenic plants.

J L Shupe, L F James

    Veterinary and Human Toxicology
    |December 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Congenital defects in livestock and humans can result from ingesting toxic plants during pregnancy. The timing of exposure during gestation significantly influences the type of malformation observed in offspring.

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    Area of Science:

    • Veterinary Medicine
    • Toxicology
    • Developmental Biology

    Background:

    • Congenital malformations are a significant issue in both livestock and human populations.
    • Historically, genetic factors were primarily blamed for congenital anomalies, but environmental influences are increasingly recognized.
    • Hazardous plants on grazing ranges are a known source of teratogenic agents.

    Purpose of the Study:

    • To investigate the role of plant-induced teratogenesis in congenital defects.
    • To understand the relationship between gestational exposure timing and defect manifestation.
    • To highlight the impact of teratogenic studies on animal and human health.

    Main Methods:

    • Review of existing literature on congenital anomalies and plant toxicities.

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  • Analysis of teratogenic studies in animal models.
  • Observation of defect types correlated with gestational exposure to specific plants.

    • Main Results:

    • Ingestion of certain plants during specific gestational periods can induce congenital defects in offspring.
    • The developmental stage of the conceptus at the time of exposure is a critical determinant of the resulting malformation.
    • Manifestations range from fetal death (reabsorption, abortion) to malformations, growth suppression, and functional disorders.

    Conclusions:

    • Plant-induced teratogenesis is a complex etiological factor in congenital defects.
    • Further research is expected to identify additional teratogenic plants.
    • Findings from animal teratogenic studies have significant benefits for the livestock industry and veterinary and human medicine.