Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human posttransfusion graft-versus-host disease.

D B Brubaker

    Vox Sanguinis
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Graft-versus-host disease (GVHD) is a fatal transfusion complication in immunocompromised patients. Early recognition and use of lymphocyte-poor or irradiated blood products can improve patient outcomes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    In vitro bleeding time test can diagnose thrombotic thrombocytopenia purpura and can possibly monitor therapeutic plasma apheresis.

    Journal of clinical apheresis·2000
    Same author

    Intravascular and total body platelet equilibrium in healthy volunteers and in thrombocytopenic patients transfused with single donor platelets.

    American journal of hematology·1998
    Same author

    Posttransfusion graft-versus-host disease in immunocompetent patients.

    Transfusion·1994
    Same author

    Correction of the corrected count increment units.

    Transfusion·1993
    Same author

    Immunopathogenic mechanisms of posttransfusion graft-vs-host disease.

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)·1993
    Same author

    The function of elevated plasma fibronectin in preeclampsia.

    American journal of obstetrics and gynecology·1992

    Area of Science:

    • Transfusion Medicine
    • Immunology
    • Hematology

    Background:

    • Graft-versus-host disease (GVHD) is a severe complication following blood product transfusions.
    • It primarily affects patients with compromised cell-mediated immunity.
    • GVHD carries a high mortality rate, ranging from 90% to 100%.

    Purpose of the Study:

    • To present the historical, clinical, pathological, and mechanistic aspects of acute and chronic GVHD.
    • To raise awareness among clinicians and transfusion therapists about this usually fatal complication.
    • To guide the selection of appropriate blood products (e.g., lymphocyte-poor or irradiated) for at-risk patients.

    Main Methods:

    • Review of historical, clinical, and pathological data related to GVHD.
    • Analysis of the mechanisms underlying acute and chronic GVHD.

    Related Experiment Videos

  • Description of patient risk factors and clinical/pathological features.

    • Main Results:

    • GVHD is a significant risk associated with blood transfusions in specific patient populations.
    • Understanding the disease's features aids in earlier recognition.
    • Identification of at-risk patients is crucial for preventative measures.

    Conclusions:

    • Increased awareness of posttransfusion GVHD is essential for improving patient management.
    • Appropriate selection of blood products can mitigate the risk of GVHD.
    • Earlier diagnosis and intervention are critical for potentially improving outcomes in this severe complication.