Role of alkaline phosphatase in contraception--a review

High-level influence of alkaline phosphatase (AP) in the endometrium is responsible for conception. Absence or reduction in the level of the same in the endometrium is one of the causes of conception control. The above mechanism is correlated with the observation of Gautray et al. (1969) on "qualitative curve of alkaline phosphatase upon the human endometrium" and the theory of "Rhythm Method"--a role in the fertility control. Conception takes place generally between the 9th and 20th day of the menstrual cycle which is indicated "Baby Days" as the enzymic AP level in the endometrium is helpful for conception and its peak level is between the 16th and 18th day. From the 1st to 8th and 21st to 28th day of the said cycle AP is at low level and almost nil. Implantation becomes unsuitable at this stage and is indicated "No Baby Days". Therefore, it may be concluded that the enzymic influence of AP is responsible both for conception and for contraception. Combined hormonal contraceptive drug also abolishes the AP influence in the endometrium. An attempt at exploration of its essential role is fundamental, because its inadequacy in the endometrium is a factor controlling conception. In view of the documents, it can be concluded that the role of AP uterine enzyme cannot be ruled out with respect to fertility control mechanism which may be considered as a fourth point instead of the three factors for the same, established in medical science.