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Intraocular pressure following aphakic transplants
Annals of Ophthalmology
|December 1, 1983
Summary
Timolol maleate did not alter initial intraocular pressure after keratoplasty with mismatched grafts. However, it reduced elevated intraocular pressure, suggesting a benefit in post-keratoplasty eye pressure management.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Intraocular pressure (IOP) management is crucial after keratoplasty.
- Graft size disparity may influence post-operative IOP.
Purpose of the Study:
- To evaluate the effect of timolol maleate on intraocular pressure following keratoplasty.
- To compare IOP outcomes with disparate versus equal-sized grafts.
Main Methods:
- Patients undergoing keratoplasty received timolol maleate.
- Intraocular pressure was measured post-operatively.
- Graft and recipient trephine sizes were recorded (7.5mm recipient/8.0mm donor vs. 8.0mm/8.0mm).
Main Results:
- Timolol maleate showed no significant difference in initial mean IOP with disparate-sized grafts.
- Timolol maleate significantly reduced the incidence of IOP elevation >24 mm Hg.
- Patients with equal-sized grafts (8.0mm) had a mean initial IOP of 19.6 mm Hg.
Conclusions:
- Timolol maleate may help mitigate IOP spikes after keratoplasty, even with graft size mismatch.
- Superficial suturing in equal-sized grafts may contribute to normal IOP by preventing angle distortion.