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The fetal prognosis in pemphigoid gestationis (herpes gestationis)

R C Holmes, M M Black

    The British Journal of Dermatology
    |January 1, 1984
    PubMed

    Insights

    Pemphigoid gestationis (herpes gestationis) in pregnancy is linked to a higher rate of infants born small for gestational age. This increases risks, highlighting the need for specialized newborn intensive care for affected pregnancies.

    Area of Science:

    • Obstetrics and Gynecology
    • Neonatology
    • Dermatology

    Background:

    • Pemphigoid gestationis (PG), also known as herpes gestationis, is a rare pregnancy-specific autoimmune blistering disease.
    • The condition poses potential risks to both the mother and the fetus.

    Purpose of the Study:

    • To investigate the fetal outcomes in pregnancies complicated by pemphigoid gestationis.
    • To assess the incidence of infants being small for gestational age (SGA) in PG pregnancies.

    Main Methods:

    • A study was conducted involving infants from fifty pregnancies diagnosed with pemphigoid gestationis.
    • Infant outcomes, specifically birth weight relative to gestational age, were analyzed.

    Main Results:

    • A significant increase in the frequency of infants born small for gestational age was observed in pregnancies affected by pemphigoid gestationis.
    • Infants born SGA are known to have higher rates of mortality and morbidity.

    Conclusions:

    • Pemphigoid gestationis is associated with impaired fetal prognosis due to the increased risk of delivering small-for-dates infants.
    • Pregnant individuals with pemphigoid gestationis require delivery in maternity units equipped with neonatal intensive care facilities.

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