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Establishment and Characterization of UTI and CAUTI in a Mouse Model

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Bacteriuria and primary biliary cirrhosis.

A K Burroughs, I J Rosenstein, O Epstein

|February 1, 1984

Summary

Women with primary biliary cirrhosis have a significantly higher rate of bacteriuria (urinary tract infections) compared to other liver diseases. This suggests a unique association between primary biliary cirrhosis and urinary tract infections, indicating increased susceptibility.

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Area of Science:

Urology
Hepatology
Infectious Diseases

Background:

Primary biliary cirrhosis (PBC) is a chronic liver disease with an unknown etiology.
Bacteriuria, the presence of bacteria in urine, is common in women and can lead to urinary tract infections (UTIs).
The relationship between PBC and bacteriuria has not been extensively studied.

Purpose of the Study:

To investigate the prevalence and characteristics of bacteriuria in women with PBC.
To compare bacteriuria rates in women with PBC to those with other chronic liver diseases and rheumatoid arthritis.
To identify factors associated with bacteriuria in PBC patients.

Main Methods:

Prospective study of 144 women with PBC over two years.
Urine specimens collected via midstream method.
Bacteriuria defined by significant bacterial counts.
Comparison with historical data from women with other liver diseases and rheumatoid arthritis.

Main Results:

19% of women with PBC had bacteriuria, compared to 7% with other liver diseases and 8% with rheumatoid arthritis.
35% of PBC patients developed bacteriuria during 12 months of follow-up.
Bacteriuria was more common in late-stage fibrotic PBC and associated with recurrent infections.
Reinfection rates were double that of women with recurrent UTIs without underlying disease.

Conclusions:

There is a unique association between primary biliary cirrhosis and bacteriuria.
PBC patients exhibit increased susceptibility to urinary tract infections.
Bacteriuria in PBC is common across all disease stages and warrants further investigation.