Related Experiment Videos
[Sensitivity to insulin in type I diabetes. Preliminary report]
Schweizerische Medizinische Wochenschrift
|December 17, 1983
Summary
Type I diabetes patients show insulin resistance at lower insulin levels but normalize glucose disposal at higher insulin concentrations. This suggests insulin resistance in type I diabetes is concentration-dependent.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Clinical Investigation
Context:
- Type I diabetes mellitus is characterized by insulin deficiency.
- Insulin resistance is a common complication in diabetes, affecting glucose metabolism.
- Understanding the dynamics of insulin sensitivity is crucial for managing diabetes.
Purpose:
- To investigate in vivo insulin sensitivity in type I diabetic subjects compared to non-diabetic controls.
- To determine the influence of varying insulin infusion rates on glucose disposal in both groups.
- To assess whether insulin resistance in type I diabetes is dependent on insulin concentration.
Summary:
- The study utilized the euglycaemic insulin clamp technique to measure insulin sensitivity in 5 type I diabetic individuals and 5 controls.
- Insulin was infused at rates of 0.5, 1.0, 2.0, and 5.0 mU/kg/min.
- Diabetic subjects exhibited insulin resistance at lower infusion rates (0.5 and 1.0 mU/kg/min) but demonstrated similar glucose disposal rates to controls at higher rates (2.0 and 5.0 mU/kg/min).
Impact:
- The findings indicate that insulin resistance in type I diabetes is dependent on the concentration of insulin.
- This highlights the importance of insulin dosage and delivery in managing hyperglycemia in type I diabetes.
- Results contribute to a better understanding of the pathophysiology of insulin resistance in diabetic patients.