Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rickets in premature infants fed different formulas.

P B Kulkarni, R D Dorand, W M Bridger

    Southern Medical Journal
    |January 1, 1984
    PubMed
    Summary

    Soy-based infant formula is linked to a high incidence of rickets in very-low-birth-weight (VLBW) infants. Researchers suggest avoiding prolonged use of soy isolate formulas in VLBW infants due to potential mineral bioavailability issues.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Earth Poultices.

    The Southern medical record·2022
    Same author

    Chemical Ecology of the host searching behavior in an Egg Parasitoid: are Common Chemical Cues exploited to locate hosts in Taxonomically Distant Plant Species?

    Journal of chemical ecology·2022
    Same author

    Toothache.

    The Dental register·2021
    Same author

    Volatiles mediate host-selection in the corn hoppers <i>Dalbulus maidis</i> (Hemiptera: Cicadellidae) and <i>Peregrinus maidis</i> (Hemiptera: Delphacidae).

    Bulletin of entomological research·2019
    Same author

    Molecular detection and characterization of Influenza 'C' viruses from western India.

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases·2017
    Same author

    Compound heterozygous variants in NBAS as a cause of atypical osteogenesis imperfecta.

    Bone·2016

    Area of Science:

    • Neonatology
    • Pediatric Nutrition
    • Nutritional Biochemistry

    Background:

    • Rickets is a significant concern in very-low-birth-weight (VLBW) infants.
    • The role of infant formula composition in rickets development requires further investigation.
    • Soy-based formulas are sometimes used for VLBW infants, but their impact on bone health is not fully understood.

    Purpose of the Study:

    • To investigate the association between different infant formulas and the incidence of rickets in VLBW infants.
    • To compare the effects of soy isolate formula versus milk-based formulas on bone metabolism markers.
    • To identify potential risks associated with soy isolate formula feeding in VLBW infants.

    Main Methods:

    • A randomized controlled trial involving 46 VLBW infants (<= 1,500 gm).

    Related Experiment Videos

  • Infants were assigned to receive Isomil (soy isolate), Similac with Iron (milk-based), or Similac 24 LBW (hypercaloric milk-based) for 3-4 months.
  • Postnatal monitoring included serum calcium, phosphorus, alkaline phosphatase, and albumin levels, along with radiologic diagnosis of rickets.

    • Main Results:

    • Rickets was diagnosed in 60% of infants fed Isomil, compared to 5% fed Similac with Iron.
    • Infants on Isomil exhibited significantly lower serum phosphorus and higher alkaline phosphatase levels.
    • No significant rickets incidence was observed in infants fed milk-based formulas.

    Conclusions:

    • Soy isolate formula is associated with a high frequency of rickets in VLBW infants.
    • Milk-based formulas did not show a similar increased risk for rickets.
    • Prolonged feeding of soy isolate formulas is not recommended for VLBW infants due to potential mineral bioavailability issues and high rickets incidence.