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Obstructive lung disease after allogeneic bone marrow transplantation.

R Kurzrock, A Zander, M Kanojia

    Transplantation
    |February 1, 1984
    PubMed
    Summary

    Chronic graft-versus-host disease can cause severe lung issues after bone marrow transplants. This obstructive lung disorder, marked by infections and respiratory failure, proved resistant to standard treatments in three patients.

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    [Not Available].

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2016

    Area of Science:

    • Pulmonology
    • Hematology
    • Immunology

    Background:

    • Allogeneic bone marrow transplantation is a life-saving procedure for various hematologic malignancies and other diseases.
    • Graft-versus-host disease (GVHD) is a significant complication following allogeneic transplantation, occurring when donor immune cells attack the recipient's tissues.
    • Chronic GVHD can affect multiple organ systems, including the lungs, leading to diverse clinical manifestations.

    Observation:

    • Three patients presented with severe dyspnea (shortness of breath).
    • These patients exhibited obstructive ventilation disorders.
    • The lung complications were associated with chronic graft-versus-host disease post-allogeneic bone marrow transplantation.

    Findings:

    • The observed lung disorder was characterized by recurrent pulmonary infections.

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  • Lower respiratory tract colonization by Pseudomonas aeruginosa was a prominent feature.
  • Two patients experienced rapid clinical deterioration, ultimately succumbing to respiratory failure.

    • Implications:

    • This case series highlights a severe, potentially fatal pulmonary complication of chronic graft-versus-host disease.
    • The findings suggest that this specific obstructive lung disorder may be refractory to conventional therapies, including antibiotics, bronchodilators, high-dose steroids, and azathioprine.
    • Further research is warranted to understand the pathogenesis and identify effective treatment strategies for this challenging clinical entity.