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Related Experiment Videos

Isosorbide dinitrate ointment in Raynaud's disease.

C Diehm, U Müller-Bühl, H Mörl

    Zeitschrift Fur Kardiologie
    |January 1, 1983
    PubMed
    Summary
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    Topical isosorbide dinitrate (ISDN) ointment did not effectively treat vasospastic Raynaud's phenomenon in a winter study. Patients reported no difference in attack frequency or duration compared to placebo.

    Area of Science:

    • Vascular Medicine
    • Dermatology
    • Pharmacology

    Background:

    • Raynaud's phenomenon is a vasospastic disorder affecting extremities.
    • Topical vasodilators are explored for symptom management.
    • Isosorbide dinitrate (ISDN) is a nitrate vasodilator.

    Purpose of the Study:

    • To evaluate the efficacy of topical isosorbide dinitrate (ISDN) ointment.
    • To assess ISDN's effect on vasospastic attacks in Raynaud's phenomenon.
    • To determine if ISDN improves digital circulation.

    Main Methods:

    • Double-blind, cross-over study design.
    • 12 patients with vasospastic Raynaud's phenomenon.
    • Treatment with ISDN ointment (200 mg) or placebo applied to fingers thrice daily for 3 weeks.

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    Main Results:

    • No significant difference in Raynaud's attack severity or duration between ISDN and placebo groups.
    • A slight, non-significant increase in digital systolic pressure and pulse amplitudes with ISDN.
    • Photoplethysmography and patient reports showed no improvement.

    Conclusions:

    • Topical isosorbide dinitrate (ISDN) ointment appears ineffective for Raynaud's phenomenon.
    • Further research may be needed to explore alternative topical treatments.
    • Vasospastic disorders require effective therapeutic strategies.