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[Streptococcus group A L-form survival in mouse peritoneal macrophages]
Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|December 1, 1983
Summary
Group A streptococci L-forms survive within mouse macrophages for up to a week. This prolonged survival, especially in vivo, may contribute to persistent infections, highlighting a potential challenge in treating streptococcal diseases.
Area of Science:
- Microbiology
- Immunology
- Cell Biology
Context:
- Group A streptococci (GAS) are significant human pathogens.
- L-forms are cell wall-defective variants of bacteria.
- Macrophage survival is crucial for bacterial persistence.
Purpose:
- To investigate the survival and intracellular fate of GAS L-forms within peritoneal macrophages.
- To compare L-form survival and phagocytosis in vitro versus in vivo.
Summary:
- GAS L-forms were studied in peritoneal macrophages of spontaneously hypertensive (SHR) mice.
- Phagocytosis of L-forms occurred within 1-3 days post-inoculation, more actively in vivo.
- Viable L-forms persisted in macrophages for 6-7 days.
Impact:
- Demonstrates the capacity of GAS L-forms to evade host immune responses within macrophages.
- Suggests a mechanism for persistent or recurrent streptococcal infections.
- Informs potential therapeutic strategies targeting bacterial persistence.