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Discovery and development of flecainide.

J M Hudak, E H Banitt, J R Schmid

The American Journal of Cardiology

|February 27, 1984

Summary

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Flecainide

Area of Science:

Medicinal Chemistry
Pharmacology
Drug Development

Background:

The discovery of flecainide began in 1966, focusing on fluorine substitution in drug molecules.
The development process was lengthy and involved distinct research phases.

Purpose of the Study:

To investigate the impact of fluorine substitution on potential drug molecules.
To develop flecainide for the treatment of cardiac arrhythmias.

Main Methods:

Synthesis and evaluation of two major chemical series incorporating fluorine.
Pharmacological assessment to shift focus towards antiarrhythmic properties.
Clinical development leading to regulatory submission.

Main Results:

Related Experiment Videos

Successful synthesis and identification of promising chemical compounds.

Transition from local anesthetic research to antiarrhythmic drug development.

Flecainide development culminated in a New Drug Application.

Conclusions:

The strategic incorporation of fluorine was key to flecainide's discovery.
A multidisciplinary approach involving chemists and pharmacologists guided its development.
Flecainide was approved for suppressing and preventing ventricular arrhythmias.